Central administration of alloxan imapirs glucose tolerance in rats (CROSBI ID 117426)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Šalković-Petrišić, Melita ; Lacković, Zdravko ; Hoyer, Siegfried ; Riederer, Peter
engleski
Central administration of alloxan imapirs glucose tolerance in rats
By means of oral glucose tolerance test (OGTT), we investigated glucose tolerance in rats pre-treated with intracerebroventricular and subcutaneous non-diabetogenic dose of betacytotoxic drug alloxan 7 days before OGTT. Being normoglycemic and normoinsulinemic pre-OGTT, at 30 minutes post-OGTT, alloxan intracerebroventricularly-treated rats had a lower glucose and a higher insulin plasma levels in comparison with controls or alloxan subcutaneously treated animals. Centrally administered alloxan seems to have within the brain effect on the regulation of peripheral glucose tolerance and insulin secretion.
Alloxan; Intracerebroventricular; Glucose; Insulin
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Podaci o izdanju
112 (10)
2005.
1391-1395
objavljeno
0300-9564
10.1007/s00702-005-0360-y
Povezanost rada
Temeljne medicinske znanosti