engleski

Effect of endosinusal treatment on cellular markers in asthmatics

The aim of the study is to determine the efficacy of topical endosinusal treatment in terms of reduction in activation of inflammatory cells and asthma symptoms in patients with asthma and chronic rhinosinusitis. Eighteen mild-to-moderate asthmatics with chronic rhinosinusitis were subjected to antral sinoscopy and endosinusal treatment with 2 mg of dexamethason and 40 mg of gentamycin per maxillary sinus for 7 days. Sinus lavage and serum samples were taken at the time of inclusion in the study. Forced expiratory volumes in first second (FEV 1) were tested at inclusion and after 30 days. Levels of eosinophil cationic protein (ECP), tryptase and myeloperoxydase were analyzed in serum and sinus fluid before and after treatment. ECP and tryptase levels were significantly reduced in serum and sinus fluid. MPO did not show significant changes after the treatment. FEV 1 significantly improved in whole group. ECP, usually used as a parameter for asthma staging, was mostly affected at the systemic level, while tryptase was more markedly reduced at the local level. The topical endosinusal treatment used in this clinical study significantly reduced activation of eosinophils and mastocytes and improved FEV 1 in mild-to-moderate asthmatics with chronic rhinosinusitis.

Asthma ; chronic rhinosinusitis ; therapy

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