engleski

Peptidoglycan monomer - product of biotechnology with immunomodulatory properties

Peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGln-mesoDpm(eNH2)-D-Ala-D-Ala, (PGM, PLIVA, Croatia) is a natural compound originating from bacterial peptidoglycan. It was produced by a simple biotechnology procedure1. Brevibacterium divaricatum was cultured in the early exponential phase of growth in the presence of penicillin, that led to the accumulation of complex, soluble peptidoglycan (PG) - containing material in the culture fluid. Digestion of PG polymer with lysozyme and subsequent purification of hydrolysis products led to the isolation of PGM. It is a non-toxic, an apyrogenic and a water-soluble compound with completely defined chemical structure. Its immunostimulative properties, resulting in adjuvant, antitumour, antimetastatic and immunorestorative activities in different models have been reviewed.

peptidoglycan monomer, adjuvant, antimetastatic, immunorestorative, metabolism of peptidoglycan

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