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Pregled bibliografske jedinice broj: 213590

Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis


Zadro, Ivana; Brinar, Vesna; Horvat, Gordana; Brinar, Marko
Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis // Clinical Neurology and Neurosurgery (2006) (znanstveni, prihvaćen)


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Naslov
Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis

Autori
Zadro, Ivana ; Brinar, Vesna ; Horvat, Gordana ; Brinar, Marko

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Clinical Neurology and Neurosurgery (2006)

Status rada
Prihvaćen

Ključne riječi
Myelin oligodendrocyte glycoprotein; Antibody; Multiple sclerosis

Sažetak
Myelin oligodendrocyte glycoprotein (MOG) is a highly immunogenic minor component on the outside surface of CNS myelin which is believed to be one of the autoantigens in multiple sclerosis. The aim of this study was to evaluate the diagnostic potential of anti-MOG IgG antibody levels in cerebrospinal fluid and serum of patients with relapsing-remitting multiple sclerosis, primary progressive multiple sclerosis and non-inflammatory neurological diseases as markers for the different clinical types of multiple sclerosis. The antibody responses to MOG were determined in paired samples of these different clinical groups by enzyme-linked immunoassay using a human MOG protein. The differences in levels were not statistically significant. The assay is not sensitive or specific enough to be used as a differential diagnostic tool for the clinical types of MS, nor for MS itself.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108042

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Zadro, Ivana; Brinar, Vesna; Horvat, Gordana; Brinar, Marko
Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis // Clinical Neurology and Neurosurgery (2006) (znanstveni, prihvaćen)
Zadro, I., Brinar, V., Horvat, G. & Brinar, M. (2006) Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis. Prihvaćen za objavljivanje u Clinical Neurology and Neurosurgery. [Preprint].
@unknown{unknown, year = {2006}, keywords = {Myelin oligodendrocyte glycoprotein, Antibody, Multiple sclerosis}, journal = {Clinical Neurology and Neurosurgery}, title = {Clinical relevance of antibodies against myelin oligodendrocyte glycoprotein in different clinical types of multiple sclerosis}, keyword = {Myelin oligodendrocyte glycoprotein, Antibody, Multiple sclerosis} }