engleski

UNDIFFERENTIATED FIBROBLASTIC SARCOMA OF OMENTUM – CASE REPORT

A 37 year old female patient was presented to the physician because of ascites and abdominal tenderness, without history of any other previous disease. Preoperative examination (CT and ultrasound of abdomen, colonoscopy and irigography) did not show any pathological disturbances. Laboratory examination found slightly elevated CA 125, CA 15-3 and CA 19. The explorative laparotomy revealed the whole omentum covered with gray-white firm tumor nodules that measured 1-3 cm in largest diameter. The serosa of the colon, ovarian surfaces and uterus were covered with numerous small white nodules, which had not been surgically removed. During laparatomy omentum was removed and pathohistologicaly analysed. The tumor located on omentum surface was white, firm with infiltrative borders, measured up to 21 cm. Frozen section was performed and the pathologist suggested possible mesenchymal tumor or reactive/inflammatory changes. Microscopically tumor was composed of sheets and cords of polygonal to round cells with prominent collagen fibers interspersed. Perivascular hyalinization was prominent and necrosis was focally present, with up to 10 mitoses per HPF. Immunohistochemical study revealed reactivity for vimentin and bcl-2, focal reactivity for CD68, CD34, CD99, SMA, MSA and EMA while CD117, CK AE1/AE3, CD 20, CD30, CD3, CD30, HMB45, desmin, alfa-aktin and s-100 were negative. The patient is currently under chemotherapy.

Fibroblastic sarcoma; Omentum

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