hrvatski

Uloga farmakogenetičkih varijacija u terapiji depresije

Genetic variations of metabolic enzymes and transporter proteins are important determinants of pharmacotherapy efficacy and toxicity. In addition, interindividual, interethnic differences in the prevalence of genetic variations are signifficanz. In this study, pharmacogenetic analysis was performed in Croatian healthy population and patients with depression. The influence of genetic variations of metabolic enzymes: CYP2C9, CYP2C19, CYP2D6, CYP3A4 and transporter proteins: P-glycoprotein (MDR1) and serotonin transporter (SERT) on pharmacologic and toxicologic effects of major depression therapy were investigated. The study included 286 healthy subjects and 114 patients with major depression.

farmakogenetičke varijacije; depresija;

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