engleski

Lipid Lowering Treatment In Secondary Stroke Prevention

Secondary preventive measures such as measur Lipid Lowering Treatment In Secondary Stroke Prevention ing serum cholesterol levels and treatment of hypercholesterolemia with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors-statins are not used enough in patients with acute stroke or transient ischemic attack, although statins offer potential benefits for reducing the incidence and improving the prognosis of stroke. Statins could have additional effects besides lipid lowering such as improvement of endothelial-dependent flow-mediated vasodilatation, modulating the inflammatory response, decreasing clot formation, and decreasing the adherence of platelets to the ruptured plaque thus stabilizing the atherosclerotic plaque. Other antiatherosclerotic properties of statins include reducing of accumulation of inflammatory cells in atherosclerotic plaques, inhibiting vascular smooth muscle cell proliferation, inhibiting platelet function, and improving of vascular endothelial function. Randomized clinical trials and evidence base medicine support the role of statin therapy in preventing ischemic stroke in patient subgroups at risk of cerebrovascular disease.

secondary prevention of stroke; lipid lowering treatment; hypercholesterolemia; statins

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