engleski

Antitumor efficancy of intrahepatic natural killer T cells in animal models

The extrathymic generation of the NKT cells were demonstrated in mice subjected to a) partial hepatectomy (pHx), b) injections of streptozotocin (provoking autoimmune diabetes) and c) injections of peptidoglycan-monomer-PGM and PGM-Zn, prepared from Gram + bacteria. In all models, freshly isolated hepatic and particularly splenic MNLC became markedly cytotoxic to YAC-1 cells, as well as to syngeneic thymocytes, suggesting that autoreactive NKT cells in the liver, might be key players in the regulation of anti-tumor immunity and epithelial cell proliferation.

Natural killer T cells; liver; partial hepatectomy; autoimmune diabetes; peptidoglycan monomer

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