engleski

Thrombolytic therapy in patients with myocardial infarction older than 75 years: the impact on infarct course and in-hospital mortality

Aim. The aim of this study was to investigate the impact of thrombolytic therapy on in-hospital course and outcome in patients with ST elevation myocardial infarction (STEMI) older than 75 years. Methods. We analyzed infarct course in 159 patients older than 75 years with STEMI (96 or 60.4% male, mean age 80.3 years), admitted to our Coronary Care Unit during the year 2000-2001. Results. In 159 patients older than 75 years with STEMI, 18 (11.3%) were treated with streptokinase. In comparison with patients who were not treated with thrombolytic therapy, they had less frequently signs of heart failure (Killip II-IV) (27.8% vs. 53.9%, p=NS). Mortality rate in thrombolytic group was lower (11.1% vs. 24.8%, p=NS), hospitalisation days were similar (14 vs. 12 days, p=NS). After thrombolytic treatment major bleeding complications did not occur. Conclusion. The results indicate that patients with STEMI older than 75 years treated with thrombolytic therapy have better infarct course and lower mortality, without major bleeding complications.

Thrombolytic therapy; Acute myocardial infarction; Elderly; Prognosis; Mortality

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