engleski

Probabilistic kinetic model of slow oxidation of LDL

Oxidation of LDL appears to play a central role in the pathogenesis of atherosclerosis. Intensive scientific efforts have been focused on the elucidation of the mechanisms by which LDL is oxidized in vivo. The probabilistic kinetic model has been developed to explain the kinetics of very slow oxidation of LDL. The model is based on a tocopherol-mediated peroxidation mechanism initiated by traces of the transition metal ions (copper) associated with LDL particles. The entire oxidation process consists of rare bursts of events in individual LDL particles. The reactions within particles are treated in terms of probabilities of individual reactive species to react with the constituent molecules. The circular flow of the radical reactions is considered as circular flow of probabilities. Theoretical quantitative kinetic model of slow oxidation of LDL have been shown to explain major features of temporal behaviour of several oxidation markers. For the application of the theory, the initial values of LDL concentration, transition metal ions (copper), a-tocopherol and lipid hydroperoxides should be determined and four or six kinetic parameters have to be selected. The fitting of the model to the experimental data suggested the values of the kinetic parameters. The kinetic length of 2, 9 in the absence of coantioxidants is shorter than found by others.

LDL oxidation; TMP; copper ions; kinetic model

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