hrvatski

Učestalost kromosomskih aberacija kao biomarker rizika za pojavu raka

Since the 1960s, chromosomal aberration frequency has been used to monitor workers occupationally exposed to genotoxic agents. It was assumed that genome damage could be associated with cancer development, but there were no studies to support this assessment due to a lack of cohorts large enough for a relible risk assessment. The results of a Nordic-Italian cohort study in the mid90s showed that chromosomal aberrations could predict cancer independently of exposure to genotoxic agent. Efforts to assess cancer risk predictivity of specific types of chromosomal aberrations as well as the predictivity of risk for specific cancer sites have continued within the scope of the EC research programme Cytogenetic Biomarkers and HUman cancer Risk. A Croatian cohort of 1320 workers monitored for CA between 1987 and 2000 formed a part of the international cohort. A follow-up of cancer incidence identified 24 cancer cases from the cohort. Relative risk of cancer in persons eith high vs. low chromosome aberration frequency was not statistically significant. The preliminary results of the poooled analysis of the international cohort show an increase in cancer risk of 80% in the top group with highest chromosome aberration frequency, but it did not reach statistical significance. In spite of the fact that the predictivity of cytogenetic biomarkers for cancer risk can be interpreted only at a group level, biomonitoring remains the only means to assess the risk in specific occupational settings and to protect populations exposed to genotoxic agents.

kromosomska aberacija; rizik za pojavu raka

Rad je kao poster prezentiran i na skupu 35th Annual meeting of the European Environmental Mutagen Society, održanom od 03.-07.07.2005., Kos, Grčka ; objavljen i u Knjizi sazetaka, str. 21-21.