POSSIBLE MECHANISMS OF IMMUNOTHERAPY IN RECURRENT SPONTANEOUS ABORTERS: ANALYSIS OF T-HELPER (Th) 1 CYTOKINES (CROSBI ID 509550)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Humar, Ines ; Puc, Maja ; Duić, Željko ; Kerhin Brkljačić, Vesna
engleski
POSSIBLE MECHANISMS OF IMMUNOTHERAPY IN RECURRENT SPONTANEOUS ABORTERS: ANALYSIS OF T-HELPER (Th) 1 CYTOKINES
Normal pregnancy is characterized by lack of strong maternal cell-mediated anti-fetal immunity and dominant humoral immune response. Since certain cytokines are propitious to the success of pregnancy, like T.helper (Th) 2 cytokines, conversely concentration Th-1 type cytokines, interleukin (Il)-2, tumor necrosis factor (TNF)-α , TNF-β and interferon-γ are potentially harmful to pregnancy. Since 1995, 45 women with history of unexplained three and more recurrent spontaneous abortion (RSA) were treated with intravenous immunoglobulin (IVIG) in the prevention of RSA. The aim of this study was to compare the concentration of Th-1 cytokines produced by women undergoing RSA with those produced during normal pregnancy and IVIG treated in similar gestation stage. The birth of child was considered a successful outcome. For women with primary RSA the success rates were 76%. Significantly increased concentration of the TNF-α were found in RSA as compared with successful pregnancy. In abortion– prone women who had a successful pregnancy, lower concentrations of TNF-α were found as compared with abortion-prone women who had another abortion, supporting the notion that Th-1 are associated with successful and unsuccessful pregnancy respectively
RECURRENT SPONTANEOUS ABORTERS; T-HELPER (Th) 1 CYTOKINES
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Podaci o prilogu
67-x.
2005.
objavljeno
Podaci o matičnoj publikaciji
Croatin Immunological Society: Annual Meeting 2005.
Podaci o skupu
Croatin Immunological Society: Annual Meeting 2005.
poster
01.01.2005-01.01.2005
Božava, Hrvatska