engleski

Oligoasthenozoospermia: To treat or not to Treat?

Pharmacotherapy of male infertility has been ever more abandoned due to uncertain results yielded by inadequate and inconsistent seminal improvement.However, different assisted reproduction techniques ranging from simple procedure like AIH through complex ones like ICSI has produced good results and raised new hope. Design; A group of oligozoospermic men from childless marriage received testolactone 150 mg/day for 3 months as an aromatization inhibitor. laboratory parameters were observed before, during and at the end of therapy.Although ased on a small patient sample, the results clearly indicated that virtually all sperm parameters could be stastistically significantly improved by the administration of testolactone. Some nonsignificant tendencies suggested that this might be related to the changes in E/T ratio. Verification of this hormonal hypothesis would obviously require a larger study group and longer therapeutic period. However, the presented improvement of sperm parameters may prove generally beneficial for the possibility of replacing ICSI by IVF in some, or IVF by AIH in other patients. This would be all but negligible if proven possible.

oligoasthenozoospermia; testolactone; estradiol; testosterone

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