engleski

Comparison of chromosome aberration frequency and spontanous abortions in female populations occupationally exposed to ionizing radiation

In order to investigate consequencies of X-ray and internal radioisotopes radiation exposure on pregnancy outcome in childbearing age women we performed follow up study using chromosome aberration assay and databank of miscarriage register. Two cohorts of Croatian health professional women employed in the radiation field during their child bearing years were identified over a period of fifteen years. Information concerning their pregnancy outcomes (as well as other individual factors, including smoking) was collected via standardized questionnaire forms. 172 women were occupationally exposed to X-ray at radiological hospital departments and 60 in the nuclear medicine and biochemical hospital departments. The miscarriage rates detected in the two groups were compared to each other, and to that of the concerned general Croatian population. Conventional chromosomal aberrations were measured in both groups. The study findings showed an increase in spontaneous abortions in the X-ray exposed group and a significant increase in the radioisotope exposed group compared to Croatian women control. Women exposed to radioisotopes experienced a threefold higher rate of spontaneous abortions than those exposed to X-ray (RR=2.9, 95%CI=1.74-4.85, p< 0.0001). Significantly higher frequencies of chromosomal aberrations were detected in both groups compared to referent values but there was no significant difference in chromosomal aberration frequency between exposed groups. For exposure levels within standard recommended guidelines, radioisotopes are far more efficient at producing spontaneous abortions than X-rays. Such biological effect is not followed by deviations in chromosomal aberration assay, a recommended biomarker for populations exposed to ionizing radiation.

radioisotopes; spontanous abortion

nije evidentirano