engleski

Chromosomal aberrations and cancer risk : a multicentric study from Central Europe

Chromosomal aberrations (CA) in peripheral blood lymphocytes (PBL) of healthy individuals might represent a marker of susceptibility to cancer, based on the concept that genetic damage in PBL reflects similar damage in cells undergoing carcinogenesis. We conducted a study based on cohorts from Croatia, Hungary, Lithuania, Poland and Slovakia ti study the association between CA levels and (specific) future cancer risk. 6430 subjects were included and followed from the date of the cytogenetic test until the date of death, cancer diagnosis, emigration, 85th birthday or and of follow up. Total CA was defined as the number of cells with aberrations, excluding gaps, per 100 cells and categorized in tertiles by laboratory. 224 subjects were diagnosed with cancer or died from a malignant tumour. The relative risk was 1.55 (95% confidence interval 1.07, 2, 26)in the medium tertile and 1.71 (95% confidence interval 1.17, 2.5) in the upper tertile, as compared with the lower tertile. No significant effect modification by either sex (p=0.26), smoking (p=0.66), age at test (p=0.86), or time since test (p=0.55) was observed. The analyses of specific types of cancer showed a relationship between CA frequency and cancer of the stomach and the colorectum, while for lung cancer the results were only suggestive of an association. No increased risk of head and neck cancer, lymphatic and haematopoietic neoplasms, breast or skin cancer was detected. The present study showed that a high freequency of CA in PBL is associated with an increased risk of cancer.

chromosomal aberration; cancer risk

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