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Pregled bibliografske jedinice broj: 208977

The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease


Bačić-Vrca, Vesna; Škreb, Franjo; Čepelak, Ivana; Mayer, Ljiljana; Kusić, Z.; Petreš, B.
The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease // Clinical chemistry and laboratory medicine, 43 (2005), 4; 383-388 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 208977 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease

Autori
Bačić-Vrca, Vesna ; Škreb, Franjo ; Čepelak, Ivana ; Mayer, Ljiljana ; Kusić, Z. ; Petreš, B.

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 43 (2005), 4; 383-388

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antioxidants; cooper; Graves disease; superoxide dismutase; total antioxidant status; zinc.

Sažetak
The effects of supplementation with a fixed combination of antioxidants (vitamins C and E, b-carotene and selenium) on superoxide dismutase activity, cooper and zinc concentration, and total antioxidant status were monitored in erythrocytes derived from a group of patients with Graves disease treated with methimazole, with respect to the rate of achieving euthyroidism.Thyroid-stimulating hormone (TSH), thyroid hormones and the above- mentioned parameters were measured before therapy, and on days 30 and 60 after therapy initiation.The patients receiving antioxidant supplementation along with methimazole therapy (group A, n=27) achieved euthyroidism at a faster rate than those treated with methimazole alone (group B, n=28). The activity of superoxide dismutase decreased significantly in both patient groups during the treatment ; however, there was no significant difference between the groups. There was no signficant change in the erythrocyte concentration of copper, whereas the zinc concentration and total antioxidant status showed significant between-group differences. the study results clearly show that antioxidant supplementation in the treatment of graves disease is justified, while zinc total antioxidant status in erythrocytes seem to be sensitive indicators of the efficacy of supplemental therapy

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
0006631
0134001

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Franjo Škreb (autor)

Avatar Url Ivana Čepelak (autor)

Avatar Url Vesna Bačić Vrca (autor)

Avatar Url Ljiljana Mayer (autor)


Citiraj ovu publikaciju

Bačić-Vrca, Vesna; Škreb, Franjo; Čepelak, Ivana; Mayer, Ljiljana; Kusić, Z.; Petreš, B.
The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease // Clinical chemistry and laboratory medicine, 43 (2005), 4; 383-388 (međunarodna recenzija, članak, znanstveni)
Bačić-Vrca, V., Škreb, F., Čepelak, I., Mayer, L., Kusić, Z. & Petreš, B. (2005) The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease. Clinical chemistry and laboratory medicine, 43 (4), 383-388.
@article{article, year = {2005}, pages = {383-388}, keywords = {antioxidants, cooper, Graves disease, superoxide dismutase, total antioxidant status, zinc.}, journal = {Clinical chemistry and laboratory medicine}, volume = {43}, number = {4}, issn = {1434-6621}, title = {The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease}, keyword = {antioxidants, cooper, Graves disease, superoxide dismutase, total antioxidant status, zinc.} }
@article{article, year = {2005}, pages = {383-388}, keywords = {antioxidants, cooper, Graves disease, superoxide dismutase, total antioxidant status, zinc.}, journal = {Clinical chemistry and laboratory medicine}, volume = {43}, number = {4}, issn = {1434-6621}, title = {The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease}, keyword = {antioxidants, cooper, Graves disease, superoxide dismutase, total antioxidant status, zinc.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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