Receptor occupancy on an ellipsoidal cell exposed to diffusion from a point source of chemoattractant (CROSBI ID 509399)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Weber, Igor
engleski
Receptor occupancy on an ellipsoidal cell exposed to diffusion from a point source of chemoattractant
Chemotactic eukaryotic cells can respond to small differences in chemoattractant concentration between the front and the back of the cell. To sense such weak gradients, cells must compare differences in receptor occupancy along their length and convert this signal into a localized response. Diffusion of a chemoattractant from a micropipette is routinely used to examine different aspects of cell’ s chemotactic response. For quantitative analysis of this response cells are usually considered to be spherical bodies, which is not appropriate for elongated cells like neutrophils and especially for amoeboid Dictyostelium cells. In order to quantify the effect of cell elongation on chemotactic sensitivity in the micropipette assay, chemoattractant concentration at the cell plasma membrane was determined by solving the equation for diffusion from a point source in the presence of a prolate ellipsoid. The results show that cell elongation can significantly increase the difference in receptor occupancy between near and far cell ends and thereby enhance sensitivity of chemotactic cells to shallow chemoattractant gradients.
Chemotaxis; Dictyostelium; Diffusion equation
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Podaci o prilogu
47-x.
2005.
objavljeno
Podaci o matičnoj publikaciji
Regional Biophysics Meeting 2005, Book of Abstracts
Abramović, Z. ; Dogša, I.
Ljubljana: Slovenian Biophysical Society
Podaci o skupu
Regional Biophysics Meeting
poster
16.03.2005-20.03.2005
Zreče, Slovenija