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izvor podataka: crosbi

Biochemical markers of bone turnover in dogs. (CROSBI ID 739983)

Prilog sa skupa u časopisu | izvorni znanstveni rad

Belić, Maja ; Kušec, Vesna ; Svetina, A. ; Turk, R. Biochemical markers of bone turnover in dogs. // Bone (New York, N.Y.). 2005. str. s387-x

Podaci o odgovornosti

Belić, Maja ; Kušec, Vesna ; Svetina, A. ; Turk, R.

engleski

Biochemical markers of bone turnover in dogs.

Biochemical bone markers provide noninvasive measurements of bone turnover and are useful in clinical practice for the better understanding of the pathogenesis and therefore better monitoring and treatment selection for certain musculo-skeletal or bone disorder. Although most of these markers which are used in humans have been shown to cross-react in dogs, still theirs measurement for assessment of bone metabolism in clinical veterinary practice is not fully established. The aim of this study was investigation of standard bone markers in dogs treated in outpatient clinic and their relationship to clinical data. The serum bone markers selected for this study were : bone alkaline phosphatase and osteocalcin as indicators of bone formation and carboxy- terminal telopeptide of type I collagen as indicator of bone resorption. Cinical data included age, body weight, sex, neutered or no- neutered status and diagnosis.The observed association between bone formation and resorption markers confirmed coupling of bone cell actions. Osteocalcin decrease with age revealed changes of skeletal growth, and the positive relationship of telopeptide with body weight indicated the impact of muscle mass on bone turnover. Analysis of age groups showed statistically significant difference for all three biochemical markers of bone turnover revealing decrease after third year of age which indicates less intensive bone turnover in mature and older dogs. There was no statistically significant difference for bone markers between genders, as well as between diagnosis groups, probably because of great variation in results and randomly taken samples. The results of this study are in agreement with literature data and the present knowledge of biochemical markers of bone turnover and bone metabolism in dogs. However, utilisation of bone markers measurement in veterinary medicine could be considered for future investigation and evaluation of bone turnover and study of bone metabolism. Further work will be required in order to establish whether there are any differences in bone turnover between sexes and dogs of different breeds.

bone; bone turnover; bone markers

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Podaci o prilogu

s387-x.

2005.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Bone (New York, N.Y.)

8756-3282

Podaci o skupu

Nepoznat skup

ostalo

29.02.1904-29.02.2096

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost