engleski

Laboratory of Neurooncology

Our laboratory studies the molecular basis of human brain tumors. The research focuses on genetic abnormalities in brain tumors with emphasis on genes that are key components of the wnt signalling pathway. The wnt pathway is often modified in human tumors and is also critical in brain developmental processes. It is named after the wnt secreted signalling proteins in mouse and man. Our particular interest lies in studying changes in APC, beta-catenin and E-cadherih genes in order to understand molecular and genetic mechanisms that govern the formation and progression of different types of brain tumors. In a major project we focus our energy on understanding and defining the the pathway of tumor formation that is critically important because it gives researchers an improved ability to detect changes in genes and predict whether a patient is likely to respond to treatment. The Laboratory of Neurooncology is also involved in the formation of the bank of brain tumor tissues. We collected and stored an extensive Brain tumor bank resource and encourage young scientists and students to research in neurooncolgy. We are also very much in the fulfillment of an educational dimension of the research carried out in our laboratory. We are collaborating with the Department of Neurology, University Hospital Sisters of Charity, Zagreb and Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre Zagreb. The range of molecular techniques in our laboratory include immunohistochemistry, Western blott, DNA extraction from tissue and blood, PCR reaction, Loss of heterozygosity analysis, RFLP and PAGE.

laboratory; neurooncology

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