engleski

Antimicrobial activity of some hydroxamic acids

Several hydroxamic acids, viz., N-benzyl-N?-hydroxysuccinamide (BHS) (1), poly[?, ?-(N-hydroxy)-DL-aspartamide] (PHA) (2), poly[a, b-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) (3) and poly [a, b-(N-hydroxy)-DL-aspartamide]/poly[a, b-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) (4) were prepared and screened for their antimicrobial activity. Ten of Gram-positive and 7 of Gram-negative species of bacteria, 5 species of Candida, 4 species of dermatophytes and 3 mould species were used in tests. Compound 1 did not showed antimicrobial activity on any of tested microorganisms. Other compounds (2-4) showed narrow spectrum of antibacterial activity, but did not showed antifungal activity.

hydroxamic acid; polyhydroxamic acid; antimicrobial activity

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