engleski

Effect of ACTH Administration on Biochemical and Immune Measures in Boars

The effects of stress induced by adrenocorticotropic hormone (ACTH) on biochemical and immune changes in Swedish Landrace boars aged approximately 6 to 7 months were observed during ACTH administration and 16 days after the cessation of treatment. ACTH treated animals (n=7) were given intravenously 10 micro g/kg body mass of ACTH for 3 days. Control group of animals (n=7) received intramuscularly 1 ml of sterile 0.9% saline. Total protein and globulin levels were significantly elevated during the induced stress period and for the next 16 days (p < 0.01 to p < 0.0001, respectively). Also, serum IgG concentration was significantly elevated during and after ACTH injection (p < 0.001 to p < 0.0001). ACTH treatment had no effect on serum albumin, IgA and IgM concentrations. Glucose concentration was significantly decreased on second day of ACTH administration (p < 0.001) and on day 9 after treatment (p < 0.001). Calcium level was significantly decreased only for 24 hours after the last ACTH dosage (p < 0.01). Also, serum phosphorus level was significantly decreased on first day (p < 0.05) and third day (p < 0.001) of ACTH challenge but remained unaffected after the cessation of ACTH treatment. It can be concluded that the administration of ACTH to boars results in immune humoral and biochemical changes during stress and in post-stress period.

adrenocorticotropic hormone; boars; immunoglobulins; serum biochemistry; stress

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