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ASSESSMENT OF THE RADIOPROTECTIVE EFFECTS OF AMIFOSTINE AND MELATONIN ON HUMAN LYMPHOCYTES IRRADIATED WITH GAMMA RAYS IN VITRO (CROSBI ID 508620)

Prilog sa skupa u zborniku | izvorni znanstveni rad | domaća recenzija

Kopjar, Nevenka ; Miočić, Slavica ; Ramić, Snježana ; Milić, Mirta ; Viculin, Tomislav ASSESSMENT OF THE RADIOPROTECTIVE EFFECTS OF AMIFOSTINE AND MELATONIN ON HUMAN LYMPHOCYTES IRRADIATED WITH GAMMA RAYS IN VITRO // Zbornik radova Šestog simpozija Hrvatskog društva za zaštitu od zračenja / Garaj-Vrhovac, Verica ; Kopjar, Nevenka ; Miljanić, Saveta (ur.). Zagreb: Hrvatsko društvo za zaštitu od zračenja, 2005. str. 194-199-x

Podaci o odgovornosti

Kopjar, Nevenka ; Miočić, Slavica ; Ramić, Snježana ; Milić, Mirta ; Viculin, Tomislav

engleski

ASSESSMENT OF THE RADIOPROTECTIVE EFFECTS OF AMIFOSTINE AND MELATONIN ON HUMAN LYMPHOCYTES IRRADIATED WITH GAMMA RAYS IN VITRO

Radioprotective effects of amifostine and melatonin on human peripheral blood irradiated with gamma-rays were investigated using the micronucleus (MN) assay and the analysis of sister chromatid exchanges (SCE). Duplicate blood samples were pre-treated with amifostine (7.7 mM), melatonin (2 mM) and their combination for 30 minutes. Negative controls were also included. After treatment with radioprotectors, one blood sample from each experimental group was exposed to gamma-rays from a 60Co source. The radiation dose absorbed was 2 Gy. Pre-treated irradiated blood samples showed a decrease in the total number of MN and in the number of cells with more than one MN. Moreover, they also showed significantly lower mean SCE values. Our results indicate that amifostine, melatonin and their combination in vitro have radioprotective effects on gamma-irradiated human peripheral blood lymphocytes, with no significant genotoxicity. Therefore, it may be reasonable to use them in combination, adjusting the doses of amifostine to achieve the best radioprotective effect with as few side effects as possible. Before employment, this combination should be extensively tested in vitro and in vivo, using the same and other biomarkers for different radiation dose and concentration ranges of both radioprotectors.

amifostine; melatonin; radioprotective effects

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Podaci o prilogu

194-199-x.

2005.

objavljeno

Podaci o matičnoj publikaciji

Zbornik radova Šestog simpozija Hrvatskog društva za zaštitu od zračenja

Garaj-Vrhovac, Verica ; Kopjar, Nevenka ; Miljanić, Saveta

Zagreb: Hrvatsko društvo za zaštitu od zračenja

Podaci o skupu

VI. Simpozij Hrvatskog društva za zaštitu od zračenja s međunarodnim sudjelovanjem

predavanje

18.04.2005-20.04.2005

Stubičke Toplice, Hrvatska

Povezanost rada

Biologija