Erythropoietic dynamic equilibrium of rats maintained after microwave irradiation (CROSBI ID 739959)
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Podaci o odgovornosti
Trošić, Ivančica ; Bušljeta, Ivana ; Pavičić, Ivan
engleski
Erythropoietic dynamic equilibrium of rats maintained after microwave irradiation
The study was aimed to assess erythropoietic homeostasis in rats during exposure to the non-thermal level of radiofrequency microwave irradiation (RF/MW, 2.45 GHz frequency, field power density 5-10 mW/cm2, specific absorption rate 1.25± ; ; 0.36 W/kg), two hours a day and seven days a week. Irradiated and matched control animals were killed after 4, 16, 30 or 60 hours of cumulative exposure. Bone marrow and blood smears were stained with acridine-orange and examined by fluorescence microscope. Bone marrow cell proliferate activity was evaluated by inspection of ratio immature/mature erythrocyte (polychromatic/normochromatic erythrocytes, PCE/NCE) during the experiment. Incidence of micronucleated polychromatic erythrocytes (MNPCE) in the bone marrow and blood was recorded by observation of 1000 PCEs/slides. In comparison with controls, analysis of bone marrow of exposed rats showed a significant increased (p<0.05) in PCE/NCE ratio after 16 and 30 irradiation hours. Bone marrow MNPCEs frequency significantly increased (p<0.05) after 30 hours of irradiation. The incidence of MNPCEs in the peripheral blood significantly increased (p<0.05) after 16 hours of cumulative exposure. From that point on, MNPCEs declined to reach control values by the end of experiment. The results indicate that selected RF/MW acts as a stressor causing reversible changes in bone marrow proliferation and maturation activity. Erythropoietic equilibrium reached at the end of 30-day experiment suggests that an adaptation mechanism of rat haematopoiesis to the selected RF/MW exposure could be involved.
Bone marrow; micronucleated polychromatic erythrocytes
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Podaci o prilogu
256-256-x.
2005.
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Podaci o matičnoj publikaciji
Toxicology letters
0378-4274
Podaci o skupu
Nepoznat skup
ostalo
29.02.1904-29.02.2096