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Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography


Vinković, Vladimir; Litvić, Mladen; Vukmanović, Karmen
Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography // Book of Abstracts
Pardubice, 2005. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography

Autori
Vinković, Vladimir ; Litvić, Mladen ; Vukmanović, Karmen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - Pardubice, 2005

Skup
11th International Symposium on Separation Sciences

Mjesto i datum
Pardubice, Češka Republika, 12-14.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
1; 4-dihidropiridini; Chiralpak AD
(1; 4-dihydropyridines; Chiralpak AD)

Sažetak
The chiral resolution of racemic drugs into their enantiomers is of great importance, because the two enantiomers often exhibit different pharmacological activity. This work deals with a group of very popular biologically active 1, 4-dihydropyridine drugs. The medicines from this class of compounds are very often used drugs for treatment of hypertension. They act as calcium antagonists and have the relaxation effect on the vascular smooth muscle cells and cardiac muscle cells. We examined the conditions for separation of 1, 4-dihydropyridine drugs compounds by high performance liquid chromatography on the analytical scale. By changing the chromatographic parameters on a number of most popular columns with chiral stationary phases, we determined optimal conditions for the separations. The analyses for the following substances were performed: isradipine, nitrendipine, nicardipine, nisoldipine, felodipine and amlodipine. The most successful separations for the all investigated compounds, except amlodipine, were achieved on Chiralpak AD column that consist of amylose tris(3, 5-dimethylphenylcarbamat) as chiral selector. This selector was proved as practically universal for chiral recognition of this class of compounds. For amlodipine, which consist the basic primary amine group, the best separation was achieve in the reverse-phase conditions at Ultron ES-OVM column. Validation of methods in selected conditions has shown that the chosen methods are selective and precise with linear response of detector for the all six pairs of enantiomers.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098051

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mladen Litvić (autor)

Avatar Url Vladimir Vinković (autor)

Citiraj ovu publikaciju

Vinković, Vladimir; Litvić, Mladen; Vukmanović, Karmen
Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography // Book of Abstracts
Pardubice, 2005. (poster, međunarodna recenzija, sažetak, znanstveni)
Vinković, V., Litvić, M. & Vukmanović, K. (2005) Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography. U: Book of Abstracts.
@article{article, year = {2005}, pages = {157}, keywords = {1, 4-dihydropyridines, Chiralpak AD}, title = {Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography}, keyword = {1, 4-dihydropyridines, Chiralpak AD}, publisherplace = {Pardubice, \v{C}e\v{s}ka Republika} }