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Pregled bibliografske jedinice broj: 201627

Combined in silico and in vitro Approach to Drug Screening


Verbanac, Donatella; Jelić, Dubravko; Stepanić, Višnja; Tatić, Iva; Žiher, Dinko; Koštrun, Sanja
Combined in silico and in vitro Approach to Drug Screening // Croatica chemica acta, 78 (2005), 2; 133-139 (recenziran, članak, stručni)


CROSBI ID: 201627 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Combined in silico and in vitro Approach to Drug Screening

Autori
Verbanac, Donatella ; Jelić, Dubravko ; Stepanić, Višnja ; Tatić, Iva ; Žiher, Dinko ; Koštrun, Sanja

Izvornik
Croatica chemica acta (0011-1643) 78 (2005), 2; 133-139

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
clustering ; compounds library ; drug discovery ; in silico ; in vitro ; screening

Sažetak
The purpose of High Throughput Screening (HTS) in pharmaceutical industry is to discover compounds that are good starting points for drug discovery. Experts from this area study the chemical structures of so called "hit" compounds that have been found to interact with the target protein, interfere with proliferation of different types of cells or disable of bacterial or fungal growth. Hypotheses to design related structures with improved biological properties are than builded. Each idea is then tested by the iterative synthesis and testing of novel compounds in various biological assays, searching for hits with better properties and defining useful and promising "lead" molecules. In parallel, molecular modeling and chemoinformatics experts can increase efficiency and decrease experimental costs by using different database filtering methods. In such a way, hits from HTS may be assessed before committing significant resource for chemical optimization. Joint efforts of these HTS experimental and modeling groups are the best way to speed up the process of finding a new useful hits and promising leads.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Pliva-Istraživački institut,
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

Hrčak

Citiraj ovu publikaciju:

Verbanac, Donatella; Jelić, Dubravko; Stepanić, Višnja; Tatić, Iva; Žiher, Dinko; Koštrun, Sanja
Combined in silico and in vitro Approach to Drug Screening // Croatica chemica acta, 78 (2005), 2; 133-139 (recenziran, članak, stručni)
Verbanac, D., Jelić, D., Stepanić, V., Tatić, I., Žiher, D. & Koštrun, S. (2005) Combined in silico and in vitro Approach to Drug Screening. Croatica chemica acta, 78 (2), 133-139.
@article{article, year = {2005}, pages = {133-139}, keywords = {clustering, compounds library, drug discovery, in silico, in vitro, screening}, journal = {Croatica chemica acta}, volume = {78}, number = {2}, issn = {0011-1643}, title = {Combined in silico and in vitro Approach to Drug Screening}, keyword = {clustering, compounds library, drug discovery, in silico, in vitro, screening} }
@article{article, year = {2005}, pages = {133-139}, keywords = {clustering, compounds library, drug discovery, in silico, in vitro, screening}, journal = {Croatica chemica acta}, volume = {78}, number = {2}, issn = {0011-1643}, title = {Combined in silico and in vitro Approach to Drug Screening}, keyword = {clustering, compounds library, drug discovery, in silico, in vitro, screening} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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