engleski

Bone morphogenetic protein expression in normal and malignant prostate and breast

Aim. It has been proposed that BMPs might act as paracrine factors regulating the proliferation and differentiation of tumor cells. Behind this background we studied the expression of BMPs in carcinoma of different origins and their normal counterparts. Methods. BMP expression was detected in 20 samples of prostate cancer, 15 samples of breast carcinoma with bone metastases and 5 normal prostate and breast samples. Tissue sections were analyzed immunohistochemically using the polyclonal anti-BMP-2/4-7 antibodies. Expression of BMPs was expressed as percentage of immunopositively stained cells. The BMP expression was compared with clinocopathological and biochemical parameters. Results. Immunohistochemical staining showed that bone morphogenetic proteins were present in the cytoplysm in prostate cells whereas breast tissues showed nuclear staining. Expression of BMP proteins was detected in prostate samples and BMP-2/4 and -7 were predominately expressed. BMP-2/4 was also predominantly expressed in prostate carcinoma while the expression of BMP-7 was significantly lower than in normal prostate. In all breast cancers tissues we found nuclear staining only for BMP-7. In normal breast tissue the BMP expression was not detectable. In breast cancer we found significantly higher percentage of BMP-7 positive cells in comparison to prostatic cancer. Comparing BMP expression levels and clinicopathological parameters, we did not find statistical difference. Conclusion. These results suggest that differed BMPs expression in prostate and breast cancer appear to be adjunct marker for osteoblastic/osteoclastic metastases presence.

BMPs; prostate cancer; breast cancer

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