What do radon daughters tell us about Alzheimer's Disease, Parkinson's Disease, and the smoking habits? Selective distribution of trace elements in the diseased human brain indicate the impairment of Cl- ion membrane transport (CROSBI ID 468041)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Momčilović, Berislav ; Alkhatib, A. Hassan ; Duerre, A. John ; Cooley, M. Alexander ; Harris, T. Robert ; Lykken, I. Glenn
engleski
What do radon daughters tell us about Alzheimer's Disease, Parkinson's Disease, and the smoking habits? Selective distribution of trace elements in the diseased human brain indicate the impairment of Cl- ion membrane transport
We studied the accumulation of the environmental radon daughters, 210Bi and 210Po, in the lipid and protein fraction of gray and white matter from the frontal and/or temporal lobe of the suman brain from subjects with Alzheimer's Disease (AD), Parkinson's Disease (PD), and smokers, amd controls with no preious signs of clinical neurological disease. 210Bi and 210Po were primarily retained in the protein fraction from the cortical gray and subcortical white matter in the brains from AD and smokers and, in contrast, in the lipid fraction in PD. This accumulation was an order of magnitude higher than that of the controls. Free radicals generated by radioactive radon daughters are a potent source of injury to the brain astrocytes. The pathognomonic distribution of radon daughters in AD, PD, and smokers is attributed to the failure of Cl- ion membrane transport and leakage
Alzheimer's Disease; Parkinson's Disease; smoking; environmental radon daughters; 210Bi; 210Po; brain proteins; brain lipids; Cl- membrane leakage; low risk radiation injury
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Podaci o prilogu
574-588-x.
1997.
objavljeno
Podaci o matičnoj publikaciji
Mengen- und Spuren-Elemente. 17 Arbeitstagung 1997
Anke, Manfred et al/
Leipzig: Verlag Harald Schubert
Podaci o skupu
Mengen und Spuren Element. 17. Arbeitstagung 1997, Friedrich Schiller Universitat, Jena
pozvano predavanje
05.12.1997-06.12.1997
Jena, Njemačka