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New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface


Moslavac Forjan, Davorka; Vinković, Vladimir
New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface // 29th International Symposium on high performance liquid phase separations and related techniques
Stockholm, Švedska, 2005. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface

Autori
Moslavac Forjan, Davorka ; Vinković, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
29th International Symposium on high performance liquid phase separations and related techniques / - , 2005

Skup
HPLC 2005

Mjesto i datum
Stockholm, Švedska, 26-30.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
chiral stationary phase; liquid chromatography

Sažetak
Liquid chromatographic resolution of enantiomers on chiral stationary phases (CSPs) has been known as one of the most convenient and accurate tool for evaluating of purity and preparative separation of enantiomers, recently even on industrial scale. Consequently, various CSPs for this purpose have been developed. Pirkle– type CSPs have been known to separate enantiomers by forming energetically different transient diastereomeric p-donor/p-acceptor complexes. For the effective formation of such complexes between the CSP and racemic analyte, Pirkle– type CSPs have been usually designed to contain p-acidic (acceptor) or/and p-basic (donor) aromatic rings. In study presented here we wish to report the process of developing a new chiral stationary phases derived from the selected amino acids. All CSPs contain a strong p-acidic N-3, 5-dinitrobenzoyl group (DNB), which is expected to interact with various aromatic derivatives, and aromatic p-basic or alkyl group which controlled the approach to silica surface. The chiral selector is covalently bound at silica surface with the spacer which is placed behind the chiral center, so that in stationary phase the chiral hole of selector is ideally open for analytes approach. With such structure the chiral selection of CSPs is remained but the achiral interaction with polar silica surface are substantially diminished.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098051

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Moslavac Forjan, Davorka; Vinković, Vladimir
New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface // 29th International Symposium on high performance liquid phase separations and related techniques
Stockholm, Švedska, 2005. (poster, međunarodna recenzija, sažetak, znanstveni)
Moslavac Forjan, D. & Vinković, V. (2005) New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface. U: 29th International Symposium on high performance liquid phase separations and related techniques.
@article{article, year = {2005}, pages = {508}, keywords = {chiral stationary phase, liquid chromatography}, title = {New Pirkle-Type Chiral Stationary Phases with Limited Approach to Silica Surface}, keyword = {chiral stationary phase, liquid chromatography}, publisherplace = {Stockholm, \v{S}vedska} }