Immune response of stressed rats treated with dextroamphetamine or propranolol (CROSBI ID 114351)
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Podaci o odgovornosti
Boranić, Milivoj ; Poljak-Blaži, Marija ; Peričić, Danka ; Manev, Hari
engleski
Immune response of stressed rats treated with dextroamphetamine or propranolol
Rats were immunized with sheep erythrocytes, and 4 days in succession were stressed by restraint for 3 hours/day, or injected with dextro-amphetamine (7.5 mg/kg/day) or propranolol (0.1 mg/kg/day), or both stressed and treated with one of the drugs. Hemolytic plaque-forming cells (PFC) were counted in the spleens on the 5th day. Stress caused marginal suppression of the PFC response. The suppression was considerably potentiated by amphetamine and negligibly so by propranolol. Effect of the drugs has been discussed in view of altered corticosterone secretion.
stress ; immune response ; dextroamphetamine ; propranolol ; rats
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