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Effect of phenoxybenzamine on the GABA system and on convulsive activity (CROSBI ID 114347)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Peričić, Danka ; Manev, Hari Effect of phenoxybenzamine on the GABA system and on convulsive activity // Neuropsychobiology, 10 (1983), 1; 23-28. doi: 10.1159/000117980

Podaci o odgovornosti

Peričić, Danka ; Manev, Hari

engleski

Effect of phenoxybenzamine on the GABA system and on convulsive activity

The effect of phenoxybenzamine on the concentration of GABA and the aminooxyacetic acid (AOAA) induced accumulation of GABA in four brain regions was compared with its effect on the occurrence and latency of picrotoxin-induced convulsions. Also the effect of phenoxybenzamine on post-decapitation convulsions was followed. Whereas 0.1 mg/kg of phenoxybenzamine decreased the levels and the AOAA-induced accumulation of GABA in the substantia nigra and cerebellar cortex, 1.0 mg/kg produced an increased GABA accumulation in the substantia nigra. Both doses of the drug decreased the AOAA-induced accumulation of GABA in the cingulate cortex. Administration of phenoxybenzamine decreased the latency and increased or decreased the occurrence of picrotoxin-induced convulsions depending on the intensity of picrotoxin effect. Phenoxybenzamine also prolonged the latency and shortened the duration of post-decapitation convulsions in rats. The results suggest that two different mechanisms mediate the effects of phenoxybenzamine on the latency and occurrence of picrotoxin-induced convulsions.

phenoxybenzamine ; GABA ; brain regions ; picrotoxin-induced convulsions ; post-decapitation convulsions

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Podaci o izdanju

10 (1)

1983.

23-28

objavljeno

0302-282X

1423-0224

10.1159/000117980

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost