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Pregled bibliografske jedinice broj: 197699

Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin


Boranić, Milivoj; Peričić, Danka; Poljak-Blaži, Marija; Šverko, Višnja; Marotti, Tatjana
Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin // Annals of the New York Academy of Sciences, 496 (1987), 485-491 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 197699 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin

Autori
Boranić, Milivoj ; Peričić, Danka ; Poljak-Blaži, Marija ; Šverko, Višnja ; Marotti, Tatjana

Izvornik
Annals of the New York Academy of Sciences (0077-8923) 496 (1987); 485-491

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-hydroxytryptophan ; para-chlorophenylalanine ; repeated stress ; PFC response ; brain monoamines ; plasma corticosterone

Sažetak
Rats immunized with sheep erythrocytes were stressed by repeated restraint and/or treated with a precursor of serotonin (5-hydroxytryptophan, 5-HTP) or with an inhibitor of serotonin synthesis (parachlorophenylalanine, PCPA). As expected, repeated stress reduced the plaque-forming cell (PFC) response. Treatment with 5-HTP also reduced the PFC response, and potentiated the immunosuppressive effect of stress. This was accompanied by increased metabolism of serotonin in the brain, as indicated by increased concentration of its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in cerebral tissue. Treatment with PCPA also suppressed the PFC response, but this suppression was accompanied by decreased levels of brain serotonin and of 5-HIAA. Plasma corticosterone levels were elevated, reaching statistical significance, in rats treated with PCPA. Both drugs suppressed the in vitro PFC response of peripheral blood lymphocytes. Thus, although 5-HTP and PCPA altered serotonin metabolism in the brain in a diametrically opposite manner, their effects on the immune response were the same. Putative central effects of the drugs on serotoninergic regulation of the immune response were apparently obscured by their effects on corticosterone secretion as well as by their direct effects on immunocompetent cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Boranić, Milivoj; Peričić, Danka; Poljak-Blaži, Marija; Šverko, Višnja; Marotti, Tatjana
Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin // Annals of the New York Academy of Sciences, 496 (1987), 485-491 (međunarodna recenzija, članak, znanstveni)
Boranić, M., Peričić, D., Poljak-Blaži, M., Šverko, V. & Marotti, T. (1987) Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin. Annals of the New York Academy of Sciences, 496, 485-491.
@article{article, year = {1987}, pages = {485-491}, keywords = {5-hydroxytryptophan, para-chlorophenylalanine, repeated stress, PFC response, brain monoamines, plasma corticosterone}, journal = {Annals of the New York Academy of Sciences}, volume = {496}, issn = {0077-8923}, title = {Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin}, keyword = {5-hydroxytryptophan, para-chlorophenylalanine, repeated stress, PFC response, brain monoamines, plasma corticosterone} }
@article{article, year = {1987}, pages = {485-491}, keywords = {5-hydroxytryptophan, para-chlorophenylalanine, repeated stress, PFC response, brain monoamines, plasma corticosterone}, journal = {Annals of the New York Academy of Sciences}, volume = {496}, issn = {0077-8923}, title = {Supression of immune response in rats by stress and drugs interfering with metabolism of serotonin}, keyword = {5-hydroxytryptophan, para-chlorophenylalanine, repeated stress, PFC response, brain monoamines, plasma corticosterone} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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