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Pregled bibliografske jedinice broj: 197418

On the mechanism of immunostimulatory activity of monomeric peptidoglycans


Hršak, Ivo; Tomašić, Jelka; Pavelić, Krešimir; Benković Kušić, Borka
On the mechanism of immunostimulatory activity of monomeric peptidoglycans // Periodicum biologorum, 81 (1979), 155-157 (međunarodna recenzija, članak, znanstveni)


Naslov
On the mechanism of immunostimulatory activity of monomeric peptidoglycans

Autori
Hršak, Ivo ; Tomašić, Jelka ; Pavelić, Krešimir ; Benković Kušić, Borka

Izvornik
Periodicum biologorum (0031-5362) 81 (1979); 155-157

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Immunostimulatory activity; peptidoglycan monomer; mitogenic activity

Sažetak
Mitogenic activity of immunostimulatory peptidoglycan monomer (PGM) was tested in vitro in short term cultures of mouse lymph node cells containing different quantities of PGM. Cultures stimulated with phytohaemagglutinin (PHA) or concavalin A (Con A) served as positive controls. As expected, PHA and Con A amplified the incorporation of radioactive thymidine into lymphocytes. PGM showed no mitogenic acitvity. Only the lymphocytes of the cultures containing 1 microgram of PGM were weakly activated. The presence of PGM suppressed even the stimulatory activity of PHA and Con A. In conclusion, PGM very probably is not a mitogen, or is only a weak one at strictly defined dose in relation to the lymphocyte number.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI