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Pregled bibliografske jedinice broj: 197373

L-ascorbic acid-induced DNA strand breaks and cross links in human neuroblastoma cells


Pavelić, Krešimir
L-ascorbic acid-induced DNA strand breaks and cross links in human neuroblastoma cells // Brain research, 342 (1985), 2; 369-373 doi:10.1016/0006-8993(85)91139-4 (međunarodna recenzija, članak, znanstveni)


Naslov
L-ascorbic acid-induced DNA strand breaks and cross links in human neuroblastoma cells

Autori
Pavelić, Krešimir

Izvornik
Brain research (0006-8993) 342 (1985), 2; 369-373

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
L-ascorbic acid ; DNA strand breaks ; cross links ; neuroblastoma cells

Sažetak
The effect of high concentrations ofl-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of young nude mice bearing human neuroblastoma with 500 mg/kgl-ascorbic acid for the first 10 days markedly inhibited the growth of tumor mass. As determined by alkaline elution, both DNA strand breaks and DNA cross links were observed in tumor cells treated with 1 × 10−4 Ml-ascorbic acid for 2 h. DNA-DNA and DNA-protein cross links in cells treated withl-ascorbic acid were revealed by the proteinase potassium assay. The results indicated thatl-ascorbic acid can be a very effective and selective agent against human neuroblastoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Krešimir Pavelić, (35262)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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