Autocrine tumor growth regulation and tumor-associated hypoglycemia in murine melanoma B16 in vivo (CROSBI ID 114226)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vuk-Pavlović, Stanimir ; Opara, E.C. ; Levanat, Sonja ; Vrbanec, Damir ; Pavelić, Krešimir
engleski
Autocrine tumor growth regulation and tumor-associated hypoglycemia in murine melanoma B16 in vivo
A substance immunochemically cross-reactive with insulin (SICRI) appears in melanoma B16 growing in diabetic and nondiabetic C57BL/6 mice. Progression of tumor size is paralleled by the increase of SICRI levels in the serum of both diabetic and nondiabetic animals ; this increase correlates with a decreased concentration of circulating glucose and an elevated concentration of growth hormone in blood. Melanoma B16 grown under serum-free culture conditions secretes SICRI into the medium. Affinity-purified SICRI stimulates glucose uptake by rat epididymal adipocytes and competes with radiolabeled insulin for binding to these cells. Low concentrations of SICRI enhance growth of cultured melanoma B16 cells, whereas high concentrations of this substance have inhibitory growth effects on these cells. Porcine insulin, human insulin-like growth factor I and II, human growth hormone, platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor have neiglibible influence on growth of melanoma B16.
autocrine tumor growth regulation ; tumor-associated hypoglycemia ; murine melanoma
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti