6-deoxy-6-bromo-ascorbic acid inhibits growth of mouse melanoma cells (CROSBI ID 114221)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Osmak, Maja ; Eckert-Maksić, Mirjana ; Pavelić, Krešimir ; Maksić, Zvonimir B. ; Spaventi, Radan ; Beketić, Lidija ; Kovaček, Ivančica ; Šušković, Božidar
engleski
6-deoxy-6-bromo-ascorbic acid inhibits growth of mouse melanoma cells
The influence of 6-deoxy-6-bromo-ascorbic acid (6-Br-AA) and ascorbic acid (AA) on the growth of mouse melanoma cell line b16, mouse fibroblasts (L929), and human cervical carcinoma HeLa cells was examined by in vitro experiments. 6-Br-AA was added in concentrations 10−1 to 10−8 M and for incubation periods of 2, 18, 24 and 72h. The present results indicate that 6-Br-AA exhibits a highly pronounced inhibiting effect on growth and DNA synthesis of melanoma cells. Inhibitory effect of 6-Br-AA was confirmed by the in vivo experiments. The tumor-suppressing effect on solid melanoma B16 was attained with 9 mg per mouse given three times daily for 16 days. Our preliminary results indicate that 6-Br-AA could serve as a potential antitumor agent.
proliferative capacity ; mouse melanoma cell ; L929 fibroblast ; potential antitumor agent ; grow cell population
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Podaci o izdanju
190 (1)
1990.
443-449
objavljeno
0300-9130
1433-8580
10.1007/BF00000050
Povezanost rada
Temeljne medicinske znanosti