engleski

Modulation of BPC Gastroprotective effect

To elucidate any mechanism, the observed events should be investigated also by the way of their modulations induced by particular organ ablation. For body protection compound (BPC), a novel partially characterized gastric juice peptide (1), the gastroprotection has been largely studied in normal and modified conditions. Between a huge range of organoprotective effects (intestinium, kidney, liver, pancreas, inflammation, diabetes mellitus), the gastroprotection has been supposed by us (1) to be firstly a crucial pattern in general concept of organoprotection, and secondly for BPC beneficial action, as the mediator of the sugested "stomach-stress organoprotective response". Therefore, the obtained modulations: (1) abolition: ovariectomy, demedullation ; (2) decrease: thyroparathyroidoectomy ; (3) no change: orchidectomy, vagotomy, spleenectomy - could probably be complex as well as specific way of BPC beneficial action. 1. Sikirić, P. et al. Exp. Clin, Gastroenterol. 1: 15-16, 1991.

BPC; gastroprotective effect

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