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Artificial reversion of acute myeloid leukemia cells into normal phenotype (CROSBI ID 114198)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavelić, Krešimir ; Baltić, Vladimir ; Spaventi, Šime Artificial reversion of acute myeloid leukemia cells into normal phenotype // International journal of biochemistry, 22 (1990), 5; 533-538. doi: 10.1016/0020-711X(90)90269-9

Podaci o odgovornosti

Pavelić, Krešimir ; Baltić, Vladimir ; Spaventi, Šime

engleski

Artificial reversion of acute myeloid leukemia cells into normal phenotype

Induction of tumor cell differentiation could reverse transformed cells into normal, mature cells. Important question is whether these malignant-to-normal reversed cells are really normal ones. We have developed an experimental model based on the examination of three different levels of human acute myeloid leukemia cell properties before and after induction of differentiation: morphological (percentage of undifferentiated blast cells), functional (DNA ploidy, Fc receptors, phagocytic activity, clonogenic assay m soft agar, oxidative metabolism which accompanies phagocytosis in mature granulocytes) and genetical (expression of oncogene p53). Several inducers have been employed: dimethylsulfoxide (DMSO) granulocyte-macrophage colony stimulating factor (GM-CSF) ; tunicamycin, interferon gamma, tumor necrosis factor and lypopolysaccharide. Our results indicate that the reversion of leukemic cells into mature normal ones with some inducers (DMSO, GM-CSF) could be a complete process.

acute myeloid leukemia ; cells

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Podaci o izdanju

22 (5)

1990.

533-538

objavljeno

0020-711X

10.1016/0020-711X(90)90269-9

Povezanost rada

Temeljne medicinske znanosti

Poveznice
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