engleski

Autocrine Tumor growth regulation by the insulin growth factor (IGF I) and the epidermal growth factor (EFG)

EGF and IGF play an important role in the regulation of cellular growth(4, 11). They interact with specific receptors on the cell surface , triggering a cascade of intracellular events wich lead to mitosis. Growth factors are necessary for cells to transit critical stages between the G0 and S phases of the cell cycle(7). These factors, like IGF I and EGF , can be synthesized in malignant cells. They induce numerous biochemical events including increased RNA and protein synthesis as cells emerge from quiescence and protein phosphorylation. Rapid protein synthesis is needed during the latter half of G1 to maintain the high level of an unstable protein which is required for a later onset of DNA synthesis. This protein accumulates in transformed cells because its greater stability (7). Various tumors produce growth factors or related proteins. In some cases progression of tumors is paralleled by elevated levels of these substances in blood or in tumor tissue. There is a growing body of evidence that these growth-promoted peptides might mediate tumor autostimulation by an autocrine mechanism (9, 11). In this study we describe the two growth -promotion molecules. IGF I and EGF, derived from human tumor tissues which play a role in autocrine growth control.

IGF I; EFG; growth factors; melanoma

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