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Pregled bibliografske jedinice broj: 196588

The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity


Sikirić, Predrag; Gyires, K.; Seiwerth, Sven; Grabarević, Željko; Ručman, Rudolf; Petek, Marijan; Rotkvić, Ivo; Turković, Branko; Udovičić, Ivan; Jagić, Vjekoslav et al.
The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity // Inflammopharmacology, 2 (1993), 121-127 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 196588 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity

Autori
Sikirić, Predrag ; Gyires, K. ; Seiwerth, Sven ; Grabarević, Željko ; Ručman, Rudolf ; Petek, Marijan ; Rotkvić, Ivo ; Turković, Branko ; Udovičić, Ivan ; Jagić, Vjekoslav ; Mildner, Boris ; Duvnjak, Marko ; Danilović, Žarko ; Kolega, Marko ; Sallmani, Ahmet ; Đačić, Sanja ; Hanzevački, Milan ; Lang, Nada ; Šimičević, Velimir ; Veljača, Marija ; Orihovac, V. ; Banić, Marko ; Brkić, Tomislav ; Buljat, Gojko ; Perović, Davor ; Miše, Stjepan ; Marović, Anton ; Šeparović, Jadranka ; Ćorić, Vedran ; Cviko, Aida ; Bura, Miljenko

Izvornik
Inflammopharmacology (0925-4692) 2 (1993); 121-127

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pentadecapeptide BPC 157; essential fragment of organoprotective gastric juice peptide BPC; writhing (acetic acid/magnesium sulphate); tail pincing test; hot-plate test; inflammatory /nin-inflammatory; indirect/direct nocicepetion; capsaicin; allodynia; ca

Sažetak
The anti-nociceptive effects of a newly synthesized pentadecapeptide coded BPC 157 (an essential fragment of new organoprotective gastric juice peptide BPC) was evaluated in comparison with aspirin and morphine reference standards, in various experimental models of indirect/direct nociception and neurotoxicity: writhing (acetic acid/magnesium sulphate), tail pinching, hot-plate, and capsaicin applicaion. BPC 157 administered either in the ng or ug per kg range, intraperitoneally, significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests. In the hot-plate test, unlike morphine, BPC 157 strongly reduced capsaicin-allodynia, either given as pretreatment or once daily for 14 days after the capsaicin injection. This reduction in capsaicin's effect could not be obtained when BPC 157 was applied in the presence of established capsaicin-somatosensory neuron degeneration (application only on the 14th day after capsaicin), so it is possible that hte effects of BPC 157 could be related specifically to the integrity of capsaicin-sensitive somatosensory neurons and their protection (e.g. primary afferent neurons having small-diameter somata and unmyelinated (C-) or thinly myelinated (Adelta-)fibres.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"


Citiraj ovu publikaciju:

Sikirić, Predrag; Gyires, K.; Seiwerth, Sven; Grabarević, Željko; Ručman, Rudolf; Petek, Marijan; Rotkvić, Ivo; Turković, Branko; Udovičić, Ivan; Jagić, Vjekoslav et al.
The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity // Inflammopharmacology, 2 (1993), 121-127 (međunarodna recenzija, članak, znanstveni)
Sikirić, P., Gyires, K., Seiwerth, S., Grabarević, Ž., Ručman, R., Petek, M., Rotkvić, I., Turković, B., Udovičić, I. & Jagić, V. (1993) The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology, 2, 121-127.
@article{article, author = {Sikiri\'{c}, Predrag and Gyires, K. and Seiwerth, Sven and Grabarevi\'{c}, \v{Z}eljko and Ru\v{c}man, Rudolf and Petek, Marijan and Rotkvi\'{c}, Ivo and Turkovi\'{c}, Branko and Udovi\v{c}i\'{c}, Ivan and Jagi\'{c}, Vjekoslav and Mildner, Boris and Duvnjak, Marko and Danilovi\'{c}, \v{Z}arko and Kolega, Marko and Sallmani, Ahmet and \DJa\v{c}i\'{c}, Sanja and Hanzeva\v{c}ki, Milan and Lang, Nada and \v{S}imi\v{c}evi\'{c}, Velimir and Velja\v{c}a, Marija and Orihovac, V. and Bani\'{c}, Marko and Brki\'{c}, Tomislav and Buljat, Gojko and Perovi\'{c}, Davor and Mi\v{s}e, Stjepan and Marovi\'{c}, Anton and \v{S}eparovi\'{c}, Jadranka and \'{C}ori\'{c}, Vedran and Cviko, Aida and Bura, Miljenko}, year = {1993}, pages = {121-127}, keywords = {pentadecapeptide BPC 157, essential fragment of organoprotective gastric juice peptide BPC, writhing (acetic acid/magnesium sulphate), tail pincing test, hot-plate test, inflammatory /nin-inflammatory, indirect/direct nocicepetion, capsaicin, allodynia, ca}, journal = {Inflammopharmacology}, volume = {2}, issn = {0925-4692}, title = {The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity}, keyword = {pentadecapeptide BPC 157, essential fragment of organoprotective gastric juice peptide BPC, writhing (acetic acid/magnesium sulphate), tail pincing test, hot-plate test, inflammatory /nin-inflammatory, indirect/direct nocicepetion, capsaicin, allodynia, ca} }
@article{article, author = {Sikiri\'{c}, Predrag and Gyires, K. and Seiwerth, Sven and Grabarevi\'{c}, \v{Z}eljko and Ru\v{c}man, Rudolf and Petek, Marijan and Rotkvi\'{c}, Ivo and Turkovi\'{c}, Branko and Udovi\v{c}i\'{c}, Ivan and Jagi\'{c}, Vjekoslav and Mildner, Boris and Duvnjak, Marko and Danilovi\'{c}, \v{Z}arko and Kolega, Marko and Sallmani, Ahmet and \DJa\v{c}i\'{c}, Sanja and Hanzeva\v{c}ki, Milan and Lang, Nada and \v{S}imi\v{c}evi\'{c}, Velimir and Velja\v{c}a, Marija and Orihovac, V. and Bani\'{c}, Marko and Brki\'{c}, Tomislav and Buljat, Gojko and Perovi\'{c}, Davor and Mi\v{s}e, Stjepan and Marovi\'{c}, Anton and \v{S}eparovi\'{c}, Jadranka and \'{C}ori\'{c}, Vedran and Cviko, Aida and Bura, Miljenko}, year = {1993}, pages = {121-127}, keywords = {pentadecapeptide BPC 157, essential fragment of organoprotective gastric juice peptide BPC, writhing (acetic acid/magnesium sulphate), tail pincing test, hot-plate test, inflammatory /nin-inflammatory, indirect/direct nocicepetion, capsaicin, allodynia, ca}, journal = {Inflammopharmacology}, volume = {2}, issn = {0925-4692}, title = {The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity}, keyword = {pentadecapeptide BPC 157, essential fragment of organoprotective gastric juice peptide BPC, writhing (acetic acid/magnesium sulphate), tail pincing test, hot-plate test, inflammatory /nin-inflammatory, indirect/direct nocicepetion, capsaicin, allodynia, ca} }

Časopis indeksira:


  • Scopus


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