Parallel synthesis and purification of 4''-O-b- aminopropionyl-8A- AND 9A- AZA-Homo-Erythromycin solution phase libraries (CROSBI ID 506819)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Hutinec, Antun ; Đerek, Marko ; Štimac, Vlado ; Alihodžić, Sulejman ; Mutak, Stjepan ; Contini, Stefania ; Paio, Alfredo
engleski
Parallel synthesis and purification of 4''-O-b- aminopropionyl-8A- AND 9A- AZA-Homo-Erythromycin solution phase libraries
8a-aza-8a-Homoerythromycins (15-membered 8a- lactams) (1) were prepared by Beckmann rearrangement of 9-(Z)-oximes. Protection of 2’ - position and acylation with 3-chloro-propionyl chloride yielded the 4''-O-acryloyl derivative. Michael reaction with aryl- or heteroaryl-alkyl substituted amines and methylene-diamines yielded 4''-O-(b-aminopropionyl) derivatives. The Michael reaction was optimized for parallel synthesis and with this technique more than 100 derivatives have been synthesized. The Parallel synthesis and purification methods for these solution phase libararies will be presented.
parallel synthesis
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Podaci o prilogu
71-71.
2005.
objavljeno
Podaci o matičnoj publikaciji
XIX. hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka
Rapić, Vladimir ; Rogošić, Marko
Zagreb: Hrvatsko društvo Kemija u industriji
9536894238
Podaci o skupu
Hrvatski skup kemičara i kemijskih inženjera (19 ; 2005)
predavanje
24.04.2005-27.04.2005
Opatija, Hrvatska