engleski

c-fms is present in primary tumours as well as in their metastases in bone marrow

The expression of c-fsm oncoprotein in different primary tumours as well as in their metastases in bone marrow, was shown. All the samples were fixed and processed by the acetone, methyl benzoate, xylene procedure (AmeX), which was suitable for studying oncoprotein expression not only in primary tumours but also in bone marrow (BM) biopsies. Among the patients suffering from acute myeloid leucemia (AmeL), positive c-fms cells were found in 55% cases. On the contrary, patients with lymphocyticcell disorders have not had detectable c-fms oncogene product in BM biopsies. There was a positive correlation between c-fms oncoprotein expression in primary and metastatic tumours. Our results showed that c-fsm produst is confined, not only to some normal, but also to the variety of malignant cells of different origin.

c-fms ; tumours ; metastases

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