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Expression of nm23-H1 gene in squamous cell carcinoma of the cervix correlates with 5-year survival


Ilijaš, Mario; Pavelić, Krešimir; Šarčević, Božena; Kapitanović, Sanja; Kurjak, Asim; Stambrook, Peter; Gluckman, J.L.; Pavelić, Zlatko
Expression of nm23-H1 gene in squamous cell carcinoma of the cervix correlates with 5-year survival // International journal of oncology, 5 (1994), 6; 1455-1457 (međunarodna recenzija, članak, znanstveni)


Naslov
Expression of nm23-H1 gene in squamous cell carcinoma of the cervix correlates with 5-year survival

Autori
Ilijaš, Mario ; Pavelić, Krešimir ; Šarčević, Božena ; Kapitanović, Sanja ; Kurjak, Asim ; Stambrook, Peter ; Gluckman, J.L. ; Pavelić, Zlatko

Izvornik
International journal of oncology (1019-6439) 5 (1994), 6; 1455-1457

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nm23-H1; squamous cell carcinoma of the cervix

Sažetak
We have examined nm23-H1 protein levels in human squamous cell carcinoma of the cervix by immunohistochemistry and correlated detectable nm23-H1 with patient survival. Normal cervical tissue samples were consistently strongly immunoreactive. In contrast, cervical carcinomas stained poorly, if at all. Well differentiated carcinomas stained more frequently for nm23-H1 protein than poorly or undifferentiated carcinomas. Our results clearly demonstrated a significant correlation between absence of nm23-H1 protein staining and shorter survival of patients with cervical cancer. Our results suggest that nm23 may serve as a potentially valuable prognostic marker for this type of tumor and to our knowledge is the first report of this kind for cervical carcinoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



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  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus