Expression of nm23-H1 gene in squamous cell carcinoma of the cervix correlates with 5-year survival (CROSBI ID 113936)
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Podaci o odgovornosti
Ilijaš, Mario ; Pavelić, Krešimir ; Šarčević, Božena ; Kapitanović, Sanja ; Kurjak, Asim ; Stambrook, Peter ; Gluckman, J.L. ; Pavelić, Zlatko
engleski
Expression of nm23-H1 gene in squamous cell carcinoma of the cervix correlates with 5-year survival
We have examined nm23-H1 protein levels in human squamous cell carcinoma of the cervix by immunohistochemistry and correlated detectable nm23-H1 with patient survival. Normal cervical tissue samples were consistently strongly immunoreactive. In contrast, cervical carcinomas stained poorly, if at all. Well differentiated carcinomas stained more frequently for nm23-H1 protein than poorly or undifferentiated carcinomas. Our results clearly demonstrated a significant correlation between absence of nm23-H1 protein staining and shorter survival of patients with cervical cancer. Our results suggest that nm23 may serve as a potentially valuable prognostic marker for this type of tumor and to our knowledge is the first report of this kind for cervical carcinoma.
nm23-H1; squamous cell carcinoma of the cervix
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti