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Pregled bibliografske jedinice broj: 196028

Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes


Li, Cl; Wu, Li; Antica, Mariastefania; Shortman, Ken; Johnson, Gregory
Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes // Experimental hematology, 23 (1995), 1; 21-25 (međunarodna recenzija, članak, znanstveni)


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Naslov
Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes

Autori
Li, Cl ; Wu, Li ; Antica, Mariastefania ; Shortman, Ken ; Johnson, Gregory

Izvornik
Experimental hematology (0301-472X) 23 (1995), 1; 21-25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
STEM CELLS ; PROTHYMOCYTES ; TRANSPLANTATION

Sažetak
Analysis of kinetics of thymic repopulation by Rh123(low), Lin(-), Ly6A/E(+), c-kit(+) (RH123(low)) cells, highly enriched for long-term in vivo hematopoietic repopulating cells, reveals that this population is deficient in thymic repopulation at week 3 after intravenous transplantation when compared to normal bone marrow cells. This suggests that the marrow prothymocytes have been depleted from this population, and analysis of thymic repopulation at week 3 can therefore be used to differentiate prothymocytes and their precursors. Using this short-term assay, the Rh123(high) Lin(-), Ly6A/E(+), c-kit(+) (Rh123(high)) population has been found to be relatively more efficient at early thymic repopulation, suggesting that this population contains the prothymocytes. In addition, the differentiation potential. and reconstitution behavior of the Rh123(high) population observed after intravenous and intrathymic transfer strongly indicates that this population is at the transitional stage between the marrow primitive pluripotential and thymic more mature lymphoid restricted stem cells. We propose that the thymic repopulating ability of the Rh123(low) population is through generation of the more mature Rh123(high) progeny, presumably in the marrow.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Citiraj ovu publikaciju

Li, Cl; Wu, Li; Antica, Mariastefania; Shortman, Ken; Johnson, Gregory
Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes // Experimental hematology, 23 (1995), 1; 21-25 (međunarodna recenzija, članak, znanstveni)
Li, C., Wu, L., Antica, M., Shortman, K. & Johnson, G. (1995) Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes. Experimental hematology, 23 (1), 21-25.
@article{article, year = {1995}, pages = {21-25}, keywords = {STEM CELLS, PROTHYMOCYTES, TRANSPLANTATION}, journal = {Experimental hematology}, volume = {23}, number = {1}, issn = {0301-472X}, title = {Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes}, keyword = {STEM CELLS, PROTHYMOCYTES, TRANSPLANTATION} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE