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Synthesis of various 1, 3-diaza- and 1-thia-3- azadibenzo(e, h)azulenes

Tricyclic compounds are well known templates for the design of bioactive molecules in thefield of new drug discovery. We have focused our attention on some anti-inflammatory 2-substituted-4, 5- diarylimidazoles and 2-substituted-4, 5- diarylthiazole analogues. Our efforts lead to preparation of two new classes of substituted dibenzo(e, h)azulenesin which the benzene rings are bridged by an oxygen or sulfur atom in a multistep synthesis starting from the known ketones 11H-dibenzo(b, f)oxepin-10-one or 11H- dibenzo(b, f)thiepin-10-one.

dibenzo[e; h]azulenes; anti-inflammatory activity; modification

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