engleski

11H-Dibenzo[b, f]oxepin-10-one and 11H-dibenzofb, f]thiepin-10-one as core units in the synthesis of various dibenzo[e, h]azulenes

Dibenzo[b, f]oxepines and dibenzo[b, f]thiepines were recognized as useful starting compounds for the synthesis of various dibenzo[e, h]azulenes which numerous derivatives show different pharmacological activities [1, 2]. Herein we wish to report some efficient syntheses of a few tetracyclic dibenzo[e, h]azulenes starting from 11H-dibenzo[b, f]oxepin-10-one and its sulphur analogue (1). Common synthetic strategy for the synthesis of different dibenzo[e, h]azulene scaffolds comprises formation of a-substituted ketones (by reaction of activated methylene group of ketones 1 with various reagents), which are further transformed into appropriate tetracyclic dibenzo[e, h]azulene system via nucleophilic substitution and elimination reaction mechanisms. According to target molecules requested, those tetracyclic compounds can be further transformed by different functional group interconversions.

dibenzo[b; f]oxepin-10-one; dibrenzo[b; f]thiepin-10-one; dibenzo[e; h]azulenes; anti-inflammatory activity; modification

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