engleski

Use of 11H-dibenzo[b, f]oxepin-10-one and 11H-dibenzo[b, f]thiepin-10-one as core units for the synthesis of various dibenzo[e, h]azulenes

The tricyclic structure of dibenzo[b, f]oxepines and dibenzo[b, f]thiepines was identified as an interesting scaffold which numerous derivatives show different pharmacological activities (antipsychotic, sedative, antidepressant, analgesic, antihypertensive, nonsteroidal anti-inflammatory, tromboxane antagonism). This broad biological activity prompted use of dibenzo[b, f]oxepines and dibenzo[b, f]thiepines as intermediates for the synthesis of various polycyclic compounds. Herein we wish to report some efficient syntheses of a few tetracyclic dibenzo[e, h]azulenes starting from 11H-dibenzo[b, f]oxepin-10-one and its sulphur analogue (1). According to target molecules requested, those tetracyclic compounds can be further transformed by different functional group interconversions.

dibenzo[e; h]azulenes; synthesis; 11H-dibenzo[b; f]oxepin-10-one; 11H-dibenzo[b; f]thiepin-10-one

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