engleski

Short Chemoenzymatic Synthesis of S-Enantiomers of Two Systemis Fungicides

2-Methyl-(4-tert-butyl)cinnamaldehyde was reduced by baker's yeast to S-3-(4-tert-butyl)-phenyl-2-propanol in high chemical and very high optical yield (99%). Chlorination and alkylation of the corresponding cyclic amines complete this short enantioselective synthesis to S-enantiomers of fenpropidine and fenpropimorph, commercialy important systemic fungicides.

Saccharomyces cerevisae; fenpropidine; fenpropimorph

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