engleski

Collision-induced Dissociation of a Series of Coumarins Studied by Positive and Negative Ion Electrospray Triple Quadrupole Tandem Mass Spectrometry

Aryl substituted 4-hydroxycoumarins (1-57) were investigated by electron spray ionisation (ESI) mass spectrometry. Their fragmentation in the ion source or in the collision cell of a triple quadrupole tandem mass spectrometer was investigated. The effect of the substituents in the aromatic ring on the fragmentation of the 4-hydroxycoumarin derivatives is shown. The influence of the tautomerism on the formation of pseudomolecular ions and mass spectral fragmentation was explained. Mass spectral studies on some deuterated compounds proved some of the proposed fragmentation pathways. Results obtained are very useful in the process of detection and characterisation of 4-hydroxycoumarins, as well as for structural elucidation of their more complex derivatives.

mass spectrometry; ESI; fragmentation; coumarins; substituents effect on fragmentation

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