Pregled bibliografske jedinice broj: 195668
RecA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein
recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein // FEMS microbiology letters, 248 (2005), 1; 119-124 doi:10.1016/j.femsle.2005.05.030 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 195668 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
RecA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein
Autori
Ahel, Ivan ; Mikoč, Andreja ; Gamulin, Vera
Izvornik
FEMS microbiology letters (0378-1097) 248
(2005), 1;
119-124
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
RecA ; Streptomyces ; C-terminus ; Transcription ; DNA damage response ; Promoter
Sažetak
Streptomyces RecA proteins are characterized by a conserved, positively charged extension of unknown function appended at their C-termini. To investigate the function of this element, we introduced Streptomyces rimosus recA gene and its mutant form encoding the protein with a C-terminal deletion into S. rimosus. Both transcript and protein levels were dramatically increased in the strain expressing the truncated gene compared to the strain bearing the wild-type recA, indicating involvement of the characteristic C-terminal extension in regulating the recA expression in Streptomyces. Considering that RecA acts as a major regulator of DNA damage response in bacteria, this mode of regulation is expected to have broader implications and significance that outreaches our current understanding of RecA autoregulation.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
