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Pregled bibliografske jedinice broj: 195668

RecA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein


Ahel, Ivan; Mikoč, Andreja; Gamulin, Vera
recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein // FEMS microbiology letters, 248 (2005), 1; 119-124 doi:10.1016/j.femsle.2005.05.030 (međunarodna recenzija, članak, znanstveni)


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Naslov
RecA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein

Autori
Ahel, Ivan ; Mikoč, Andreja ; Gamulin, Vera

Izvornik
FEMS microbiology letters (0378-1097) 248 (2005), 1; 119-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
RecA ; Streptomyces ; C-terminus ; Transcription ; DNA damage response ; Promoter

Sažetak
Streptomyces RecA proteins are characterized by a conserved, positively charged extension of unknown function appended at their C-termini. To investigate the function of this element, we introduced Streptomyces rimosus recA gene and its mutant form encoding the protein with a C-terminal deletion into S. rimosus. Both transcript and protein levels were dramatically increased in the strain expressing the truncated gene compared to the strain bearing the wild-type recA, indicating involvement of the characteristic C-terminal extension in regulating the recA expression in Streptomyces. Considering that RecA acts as a major regulator of DNA damage response in bacteria, this mode of regulation is expected to have broader implications and significance that outreaches our current understanding of RecA autoregulation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
0098072

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Vera Gamulin (autor)

Avatar Url Andreja Mikoč (autor)

Avatar Url Ivan Ahel (autor)

Citiraj ovu publikaciju

Ahel, Ivan; Mikoč, Andreja; Gamulin, Vera
recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein // FEMS microbiology letters, 248 (2005), 1; 119-124 doi:10.1016/j.femsle.2005.05.030 (međunarodna recenzija, članak, znanstveni)
Ahel, I., Mikoč, A. & Gamulin, V. (2005) recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein. FEMS microbiology letters, 248 (1), 119-124 doi:10.1016/j.femsle.2005.05.030.
@article{article, year = {2005}, pages = {119-124}, DOI = {10.1016/j.femsle.2005.05.030}, keywords = {RecA, Streptomyces, C-terminus, Transcription, DNA damage response, Promoter}, journal = {FEMS microbiology letters}, doi = {10.1016/j.femsle.2005.05.030}, volume = {248}, number = {1}, issn = {0378-1097}, title = {recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein}, keyword = {RecA, Streptomyces, C-terminus, Transcription, DNA damage response, Promoter} }
@article{article, year = {2005}, pages = {119-124}, DOI = {10.1016/j.femsle.2005.05.030}, keywords = {RecA, Streptomyces, C-terminus, Transcription, DNA damage response, Promoter}, journal = {FEMS microbiology letters}, doi = {10.1016/j.femsle.2005.05.030}, volume = {248}, number = {1}, issn = {0378-1097}, title = {recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein}, keyword = {RecA, Streptomyces, C-terminus, Transcription, DNA damage response, Promoter} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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